On the Mechanism of Action of the Cytostatic Drug Anguidine and of the Immunosuppressive Agent Ovalicin, two Sesquiterpenes from Fungi1
نویسندگان
چکیده
A a t the low concentration of lo-* moll1 inhibit protein synthesis in lymphocytes The sesquiterpene betainyl-anguidine from mouse spleen rapidly after addiand the structurally related verrucarin .tion to the cell culture. DNA svnthesis 1 Dedicated 10 Professor ADOLF BUTENANDT is at low 'Oncentrafin the occasion of his 75th birthday. tions whereas RNA synthesis is much T hi s do cu m en t w as d ow nl oa de d fo r pe rs on al u se o nl y. U na ut ho riz ed d is tr ib ut io n is s tr ic tly p ro hi bi te d.
منابع مشابه
On the mechanism of action of the cytostatic drug anguidine and of the immunosuppressive agent ovalicin, two sesquiterpenes from fungi.
A a t the low concentration of lo-* moll1 inhibit protein synthesis in lymphocytes The sesquiterpene betainyl-anguidine from mouse spleen rapidly after addiand the structurally related verrucarin .tion to the cell culture. DNA svnthesis 1 Dedicated 10 Professor ADOLF BUTENANDT is at low 'Oncentrafin the occasion of his 75th birthday. tions whereas RNA synthesis is much T hi s do cu m en t w as ...
متن کاملThe significance of determining the therapeutic dose of cyclosporine-A in patients undergoing organ transplantation
Immunosuppressive drugs are now unavoidibly used after the transpantation of liver,heart and bone marrow, as well as in certain autoimmune diseases.among these agents,cyclosporine-A (CYA) is one of the most effective Immunosuppressants which is widely used.but as any Immunosuppressive agent,the use of CYA is not without harmful side effects.neurotoxin,nephrotoxic and hepatotoxic complications,m...
متن کاملTherapeutic Drug Monitoring of Sirolimus,Correlation With Laboratory Parameters In Transplant Patients
Sirolimus is a potent immunosuppressive agent administered as prophylactic agent to prevent rejection after organ transplantation. Sirolimus must be used within a narrow therapeutic window. Due to inter- and intra-variability, sirolimus blood concentrations may be affected, therefore, there is no possibility of predicting the sirolimus blood concentrations based on the dose patients received. T...
متن کاملApoptotic effect of morphine, imiquimod and nalmefene on promastigote , infected and uninfected macrophages with amastigote of Leishmania major by flow cytometry
The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases. According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse as well as financial burden. The mechanism of action of opioid drugs are primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomo...
متن کاملApoptotic effect of morphine, imiquimod and nalmefene on promastigote , infected and uninfected macrophages with amastigote of Leishmania major by flow cytometry
The parasites of genus Leishmania are the causative agents of one of the most widespread and devastating diseases. According to follow-up data, these medications may provoke adverse drug reactions, drug resistance, relapse as well as financial burden. The mechanism of action of opioid drugs are primarily exerted via transmembrane G-protein coupled receptors. One of the potent synthetic immunomo...
متن کامل